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Wednesday, July 22, 2020 | History

2 edition of novel model for the prediction of chemically induced acute eye irritation. found in the catalog.

novel model for the prediction of chemically induced acute eye irritation.

Wendy Joyce Bacon

novel model for the prediction of chemically induced acute eye irritation.

by Wendy Joyce Bacon

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  • 40 Currently reading

Published by University of Salford in Salford .
Written in English


Edition Notes

MSc thesis, Biological Sciences.

ID Numbers
Open LibraryOL20309464M

Single Intravenous Dose of Novel Flurbiprofen-Loaded Proniosome Formulations Provides Prolonged Systemic Exposure and Anti-inflammatory EffectCited by: 6. The nematode, Caenorhabditis elegans, as an emerging model for investigating epilepsy / Cody J. Locke, Kim A. Caldwell, and Guy A. Caldwell -- The genetics and molecular biology of seizure susceptibility in drosophila / Juan Song and Mark A. Tanouye -- The albino Xenopus laevis tadpole as a novel model of developmental seizures / D. Sesath.

  title = "Pharmacologically induced preconditioning with diazoxide: A novel approach to brain protection", abstract = "Background. Ischemic preconditioning is an endogenous mechanism whereby brief periods of ischemia render neurons resistant to subsequent lethal by: Novel agents targeting antigens on the lymphoblast cell surface offer unique side effect and anti-leukemic profiles which suggest that their use alone or in combination with chemotherapy may achieve improved outcomes for relapsed or refractory ALL. Michaela. / Current therapy and novel agents for relapsed or refractory acute lymphoblastic Cited by:

THIS by no means purports to be a complete review of the recent literature concerning allergy in childhood. I have concentrated on a few broad subjects only, some of Cited by:   Purchase Immunology, Inflammation and Diseases of the Eye - 1st Edition. Print Book & E-Book. ISBN ,


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Novel model for the prediction of chemically induced acute eye irritation by Wendy Joyce Bacon Download PDF EPUB FB2

A year later, it was shown that soaps and shampoos that were, by experience, painful when applied to the eye could activate the TRPV1 channel in. the detergent sodium lauryl sulfate dose-dependently induced Ca21 influxes that could be addressed to TRPV1.

These results reveal a novel mechanistic pathway for surfactant-induced nociception, which may be an important endpoint in in vitro test batteries as alternatives to Draize’s rabbit eye test for classification of eye irritating products.

Results. Compared to the saline group, the TNBS-treated goats showed apparent transmural pathological changes and a significant increase (P Cited by: 1.

Analysis of Draize eye irritation testing and its prediction by mining publicly available REACH data Article (PDF Available) January with Reads How we measure 'reads'.

Evaluation of potential chemical-induced eye injury through irritation and corrosion is required to ensure occupational and consumer safety for industrial, household and cosmetic ingredient chemicals.

The historical method for evaluating eye irritant and corrosion potential of chemicals is the rabbit Draize by: 8. Acute toxicity tests—namely, skin and eye irritation, skin sensitization, and systemic (oral, dermal, and inhalation) toxicity—are commonly conducted on medical devices, pesticides, industrial chemicals, pharmaceuticals, cosmetics, and other substances.

Hemi-cornea test protocol for eye irritation Liquid test chemicals protocol. The tissues were transferred from the well plates into the upper row of 6-well plates (one tissue per well) containing 1 ml of KGM and pre-incubated for one hour at 95% relative humidity, 37 °C, and 5% CO 2 in the atmosphere.

Thereafter, 50 μl of liquid test substances as well as DPBS (NC) and Cited by: GASTROENTEROLOGY ; A Novel Method in the Induction of Reliable Experimental Acute and Chronic Ulcerative Colitis in Mice ISA0 OKAYASU, SHIGERU HATAKEYAMA, MASAHIRO YAMADA, TOSHIFUMI OHKUSA, YOSHIO INAGAKI, and RINTARO NAKAYA Departments of Pathology, 1st Internal Medicine, and Microbiology, Cited by: Chemically produced dry eye syndrome should not be confused with Sjeogren's syndrome which also causes dry eyes and can be ruled out with appropriate tests [Bell et al., ; Manoussakis and Moutsopoulos, ; Rice, ].A routine eye examination does not include a test for dry eye syndrome which therefore often goes undiagnosed.

model of raccoon-rabies invasion across the state of Connecticut. Use of this model provides a rare example of. a priori. prediction of an epidemic invasion over a naturally heterogeneous landscape. Model predictions matched to data can also be used to evaluate the most likely points of disease introduction.

4 Assays for Predicting Acute Toxicity. The future path of toxicity testing was foreshadowed early in the s with publication of frameworks or roadmaps that called for an increased emphasis on the use of in vitro assays that evaluate key biological pathways and molecular mechanisms linked to human disease (EPA ; NTP ).

Whilst numerous studies investigating the aetiology of inflammatory diseases have been performed in rodents, the applicability of these data to human pathophysiology is frequently debated. Regardless of. Furthermore, mechanisms for chemically induced nociception are studied in a recombinant neuronal cell model expressing the Transient Receptor Potential Vanilloid (TRPV) ion channels.

The latter research has resulted in the development and evaluation of a cell culture model that holds promise to replace the Draize eye irritation test that is.

The new model was compared with simple allometric scaling and the ‘rule of exponents’ (ROE). Results indicated that the new model provided better predictability for human values of CL than ROE. It is especially significant that for the first time the proposed model improves the prediction of CL for drugs illustrating large vertical by: which the identification and prediction is done using a new data-driven method.

The key objective of this study is to develop a real time model that forecasts the AROT for different aircraft types and weather conditions using this new data-driven method for Charles de Gaulle (CDG) and Vienna (VIE) airport.

Washington, DC: The National Academies Press. doi: / such as genotoxicity, skin irritation, and eye irritation.

Data from in vitro and in silico models, however, are, or will be, available for a far larger number of chemicals than experimental or epidemiological data will be (Collins et al. the region of a chemical. Visceral hypersensitivity (VH) is a common condition in many gastrointestinal disorders such as inflammatory bowel diseases (IBDs) in human and animals.

Most studies often induce Crohn’s disease/colitis to investigate VH in small experimental animals. Although farm animals commonly suffer from IBDs, their VH has not been investigated so far.

Because goats Cited by: 1. +*Anderson C, Sundberg K, Groth O. Animal model for assessment of skin irritancy. Contact Dermatitis *Aoki K, Zhao W, Misumi J, et al. Changes in 2,5-hexanedione concentration in the sciatic nerve, serum and urine of rats induced by combined administration of 2,5-hexanedione with acetone or methyl ethyl ketone.

The duration of the observation period was limited to 24 h, which would include the acute but not the delayed emetic response to cytotoxic drugs (e.g. cisplatin, Percie du Sert et al., ).

Depending on the drugs and the studies, the observation period varied from 30 min to 24 h, and some reports included in the present study may have used an Cited by:   Predicting the next eye pathogen; analysis of a novel adenovirus by Massachusetts Eye and Ear Infirmary The ongoing dance between a virus and its host distinctly shapes how the virus evolves.

There have been many attempts to identify and develop new uses for existing drugs, which is known as drug repositioning. Among these efforts, text mining is an effective means of discovering novel knowledge from a large amount of literature data. We identify a gene regulation by a drug and a phenotype based.T1 - A novel method to model chronic traumatic encephalopathy in Drosophila.

AU - Sun, Mingkuan. AU - Chen, Liam Lucian. PY - /7/4. Y1 - /7/4. N2 - Chronic Traumatic Encephalopathy (CTE) is an established neurodegenerative disease that is closely associated with exposure to repetitive mild Traumatic Brain Injury (mTBI).Cited by: 2.The full text of this article hosted at is unavailable due to technical difficulties.